原创力文档cardiovascular benefits of glp-1-basedtherapies in patients with diabetes mellitus type 2 effects on endothelial and vascular dysfunction beyond glycemic control糖尿病患者的心血管益处glp-1-basedtherapies 2型对内皮细胞和血管功能障碍除了血糖控制的影响.pdfVIP
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cardiovascular benefits of glp-1-basedtherapies in patients with diabetes mellitus type 2 effects on endothelial and vascular dysfunction beyond glycemic control糖尿病患者的心血管益处glp-1-basedtherapies 2型对内皮细胞和血管功能障碍除了血糖控制的影响
Hindawi Publishing Corporation
Experimental Diabetes Research
Volume 2012, Article ID 635472, 9 pages
doi:10.1155/2012/635472
Review Article
Cardiovascular Benefits of GLP-1-Based Therapies
in Patients with Diabetes Mellitus Type 2: Effects on Endothelial
and Vascular Dysfunction beyond Glycemic Control
1, 2 2 ¨ 1
Thomas Forst, Matthias M. Weber, and Andreas Pfutzner
1 Institute for Clinical Research and Development, 55116 Mainz, Germany
2 First Medical Department, Johannes Gutenberg University, Mainz, Germany
Correspondence should be addressed to Thomas Forst, thomasf@ikfe.de
Received 4 January 2012; Accepted 6 February 2012
Academic Editor: Matteo Monami
Copyright © 2012 Thomas Forst et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Type 2 diabetes mellitus (T2DM) is a progressive multisystemic disease accompanied by vascular dysfunction and a tremendous
increase in cardiovascular mortality. Numerous adipose-tissue-derived factors and beta cell dysfunction contribute to the increased
cardiovascular risk in patients with T2DM. Nowadays, numerous pharmacological interventions are available to lower blood
glucose levels in patients with type 2 diabetes. Beside more or less comparable glucose lowering efficacy, some of them have shown
limited or probably even unfavorable effects on the cardiovascular system and overall mortality. Recently, incretin-based therapies
(GLP-1 receptor agonists and DPP-IV inhibitors) have been introduced in the treatment of T2DM. Beside the effects of GLP-1 on
insulin secretion,
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