case report of undifferentiated endometrial sarcoma in association with osteoclast-like giant cells未分化子宫内膜癌肉瘤的病例报告与osteoclast-like巨大细胞.pdfVIP

SAGE-Hindawi Access to Research Pathology Research International Volume 2011, Article ID 629840, 5 pages doi:10.4061/2011/629840 Case Report Case Report of Undifferentiated Endometrial Sarcoma in Association with Osteoclast-Like Giant Cells Svetoslav Bardarov, Vadim Khachaturov, Patel Kirtesh, and Elpidio Jimenez Department of Pathology, 97 Amity Street, Brooklyn, NY 11201, USA Correspondence should be addressed to Svetoslav Bardarov, savcob@ Received 7 October 2010; Accepted 4 February 2011 Academic Editor: George L. Mutter Copyright © 2011 Svetoslav Bardarov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We describe the clinical, gross and microscopic features of undifferentiated uterine stromal sarcoma associated with osteoclast- like giant cells. A case of low-grade endometrial stromal sarcoma is already described in association with osteoclast-like giant cells; however, the current case differs in that the tumor was a high grade and did not show any evidence of smooth muscle or epithelioid differentiation and was shown to be strongly positive for CD10 and focally for WT-1 and Inhibin supporting an endometrial stromal origin. The associated osteoclast-like giant cells were abundant, evenly distributed within the tumor and showed strong positivity for CD68. Interestingly, rare (less than 2%) giant cells also showed weak cytoplasmic positivity for b-hCG. The tumor infiltrated deep into the myometrium and had marked lymphovascular invasion. Although the regional lymph nodes and peritoneal washings were negative, the lesion showed a highly aggressive clinical course. Despite treatment, the tum