原创力文档catalytic therapy of cancer with ascorbate and extracts of medicinal herbs催化癌症治疗与抗坏血酸盐和中药材的提取.pdfVIP
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catalytic therapy of cancer with ascorbate and extracts of medicinal herbs催化癌症治疗与抗坏血酸盐和中药材的提取
Advance Access Publication 26 December 2007 eCAM 2010;7(2)203–212
doi:10.1093/ecam/nem159
Original Article
Catalytic Therapy of Cancer with Ascorbate and Extracts
of Medicinal Herbs
1 1 2
Nadejda Rozanova (Torshina) , Jin Z. Zhang and Diane E. Heck
1Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064 and 2Department of
Cancer Biology and Pharmacology, University of Illinois College of Medicine, Peoria, IL 61605, USA
Catalytic therapy (CT) is a cancer treatment modality based on the generation of reactive
oxygen species (ROS) using a combination of substrate molecules and a catalyst. The most
frequently used substrate/catalyst pair is ascorbate/Co phthalocyanine (PcCo). In the present
work, herb extracts containing pigments have been studied as a catalyst in place of PcCo.
Extracts from herbs are expected to have efficiency comparable with that of phthalocyanines
but as natural products, to exhibit fewer side effects. The present studies demonstrate that a
combined use of ascorbate and herbal extracts results in ROS production and a significant
decrease in the number of cancer cells after a single in vitro treatment. Treatment with ascorbate
in conjunction with extracts prepared from
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