cell stress proteins in atherothrombosis细胞应激蛋白质壁血栓.pdfVIP

Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity Volume 2012, Article ID 232464, 10 pages doi:10.1155/2012/232464 Review Article Cell Stress Proteins in Atherothrombosis Julio Madrigal-Matute, Roxana Martinez-Pinna, Carlos Ernesto Fernandez-Garcia, Priscila Ramos-Mozo, Elena Burillo, Jesus Egido, Luis Miguel Blanco-Colio, and Jose Luis Martin-Ventura Vascular Research Laboratory, IIS-Fundacion Jimenez Dıaz, Universidad Autonoma de Madrid, 28040 Madrid, Spain ´ ´ ´ ´ Correspondence should be addressed to Julio Madrigal-Matute, jmadrigal@fjd.es Received 30 March 2012; Accepted 14 May 2012 Academic Editor: Ana Fortuno Copyright © 2012 Julio Madrigal-Matute et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cell stress proteins (CSPs) are a large and heterogenous family of proteins, sharing two main characteristics: their levels and/or location are modified under stress and most of them can exert a chaperon function inside the cells. Nonetheless, they are also involved in the modulation of several mechanisms, both at the intracellular and the extracellular compartments. There are more than 100 proteins belonging to the CSPs family, among them the thioredoxin (TRX) system, which is the focus of the present paper. TRX system is composed of several proteins such as TRX and peroxiredoxin (PRDX), two thiol-containing enzymes that are key players in redox homeostasis due to their ability to scavenge potential harmful reactive oxygen species. In addition to their main role as antioxidants, recent