cellulases from thermophilic fungi recent insights and biotechnological potential多种纤维素酶的嗜热真菌最近的见解和生物技术的潜力.pdfVIP

SAGE-Hindawi Access to Research Enzyme Research Volume 2011, Article ID 308730, 9 pages doi:10.4061/2011/308730 Review Article Cellulases from Thermophilic Fungi: Recent Insights and Biotechnological Potential Duo-Chuan Li,1 An-Na Li,1 and Anastassios C. Papageorgiou2 1 Department of Environmental Biology, Shandong Agricultural University, Taian, Shandong 271018, China 2 ˚ Turku Centre for Biotechnology, University of Turku and Abo Akademi University, 20521 Turku, Finland Correspondence should be addressed to Anastassios C. Papageorgiou, tassos.papageorgiou@btk.fi Received 6 June 2011; Revised 5 September 2011; Accepted 7 September 2011 Academic Editor: D. M. G. Freire Copyright © 2011 Duo-Chuan Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Thermophilic fungal cellulases are promising enzymes in protein engineering efforts aimed at optimizing industrial processes, such as biomass degradation and biofuel production. The cloning and expression in recent years of new cellulase genes from thermophilic fungi have led to a better understanding of cellulose degradation in these species. Moreover, crystal structures of thermophilic fungal cellulases are now available, providing insights into their function and stability. The present paper is focused on recent progress in cloning, expression, regulation, and structure of thermophilic fungal cellulases and the current research efforts to improve their properties for better use in biotechnological applications. 1. Introduction new thermostable enzymes