cancer, inflammation, and insights from ayurveda癌症、炎症、从阿育吠陀和见解.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 306346, 11 pages doi:10.1155/2012/306346 Review Article Cancer, Inflammation, and Insights from Ayurveda Venil N. Sumantran1 and Girish Tillu2 1 Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600 036, India 2 Symbiosis School of Biomedical Sciences, Symbiosis International University, Pune 412115, India Correspondence should be addressed to Venil N. Sumantran, vns@ Received 1 December 2011; Revised 9 April 2012; Accepted 7 May 2012 Academic Editor: Tieraona Low Dog Copyright © 2012 V. N. Sumantran and G. Tillu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A recent, exciting discovery relates to the concept of “shared pathology” between cancer and metabolic syndrome. One major path- way common to cancer and metabolic syndrome is chronic inflammation, which is a major driving force in carcinogenesis. Indeed, chronic inflammation precedes most cancers and is considered a “hallmark” of the neoplastic process. We discuss molecular and biochemical evidence which links diet, obesity, abnormal lipid metabolism, and type 2 diabetes mellitus with chronic inflam- mation. We also explain how each of these factors is linked with biochemical aberrations of carcinogenesis and the prevalence and risk of cancer. While there are reliable biomarkers for chronic inflammation, there are few markers for a mechanistic link between early inflammation and digestive disorders. Discovery of such a marker could lead to identification of a new subtype of patients with digest