canonical and alternative pathways in cyclin-dependent kinase 1cyclin b inactivation upon m-phase exit in xenopus laevis cell-free extracts规范和替代途径在细胞周期蛋白依赖性激酶1 b细胞周期蛋白失活在有丝分裂期退出非洲爪蟾蜍光滑的无细胞提取物.pdfVIP

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canonical and alternative pathways in cyclin-dependent kinase 1cyclin b inactivation upon m-phase exit in xenopus laevis cell-free extracts规范和替代途径在细胞周期蛋白依赖性激酶1 b细胞周期蛋白失活在有丝分裂期退出非洲爪蟾蜍光滑的无细胞提取物.pdf

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canonical and alternative pathways in cyclin-dependent kinase 1cyclin b inactivation upon m-phase exit in xenopus laevis cell-free extracts规范和替代途径在细胞周期蛋白依赖性激酶1 b细胞周期蛋白失活在有丝分裂期退出非洲爪蟾蜍光滑的无细胞提取物

SAGE-Hindawi Access to Research Enzyme Research Volume 2011, Article ID 523420, 8 pages doi:10.4061/2011/523420 Review Article Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1/Cyclin B Inactivation upon M-Phase Exit in Xenopus laevis Cell-Free Extracts Jacek Z. Kubiak and Mohammed El Dika Cell Cycle Group, Institute of Genetics Development, University of Rennes 1, CNRS-UMR 6061, Faculty of Medicine, 2 Avenue Prof. Leon Bernard, CS 34317, 35043 Rennes Cedex, France ´ Correspondence should be addressed to Jacek Z. Kubiak, jacek.kubiak@univ-rennes1.fr Received 25 February 2011; Revised 1 April 2011; Accepted 18 April 2011 Academic Editor: Heung Chin Cheng Copyright © 2011 J. Z. Kubiak and M. El Dika. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cyclin-Dependent Kinase 1 (CDK1) is the major M-phase kinase known also as the M-phase Promoting Factor or MPF. Studies performed during the last decade have shown many details of how CDK1 is regulated and also how it regulates the cell cycle progression. Xenopus laevis cell-free extracts were widely used to elucidate the details and to obtain a global view of the role of CDK1 in M-phase control. CDK1 inactivation upon M-phase exit is a primordial process leading to the M-phase/interphase transition during the cell cycle. Here we discuss two closely related aspects of CDK1 regulation in Xenopus laevis cell-free extracts: ﬁrstly, how CDK1 becomes inactivated and secondly, how other actors, like kinases and phosphatases network and/or speciﬁc inhibitors, cooperate with CDK1 inactivation to assure timely exit from the M-pha