原创力文档cardiac and renal function are progressively impaired with aging in zucker diabetic fatty type ii diabetic rats心脏和肾脏功能逐步受损衰老zucker糖尿病脂肪ii型糖尿病的老鼠.pdfVIP
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cardiac and renal function are progressively impaired with aging in zucker diabetic fatty type ii diabetic rats心脏和肾脏功能逐步受损衰老zucker糖尿病脂肪ii型糖尿病的老鼠
ReseaRCh papeR
Oxidative Medicine and Cellular Longevity 2:5, 328-334; November/December 2009; © 2009 Landes Bioscience
Cardiac and renal function are progressively impaired
with aging in Zucker diabetic fatty type II
diabetic rats
1 2,
John Baynes and David B. Murray *
1Department of Exercise Science; University of South Carolina; Columbia, SC USA; and 2 Department of Pharmacology; University of Mississippi School of
Pharmacy; Oxford, MS USA
Key words: cardiomyopathy, diabetes, hydronephrosis
This study investigated the temporal relationship between cardiomyopathy and renal pathology in the type II diabetic
Zucker diabetic fatty (ZDF) rat. We hypothesized that changes in renal function will precede the development of cardiac
dysfunction in the ZDF rat. animals (10 weeks old) were divided into four experimental groups: Lean Control (fa/?) LC
(n = 7), untreated ZDF rats (n = 7) sacrificed at 16 weeks of age, and LC (n = 7) untreated ZDF rats (n = 9) sacrificed at
36 weeks of age. LV structural/functional parameters were assessed via Millar conductance catheter. Renal function was
evaluated via markers of proteinuria and evidence of hydronephrosis. LV mass was significantly less in the ZDF groups at
both time points compared to age-matched LC. End diastolic volume was increased by 16% at 16 weeks and by 37% at 36
weeks of age (p 0.05 vs. LC). End diastolic pressure and end systolic volume were significantly increased (42% and 27%
respectively) at 36 weeks of age in the ZDF compared t
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