cardiac autonomic imbalance in newly diagnosed and established diabetes is associated with markers of adipose tissue inflammation心脏自主神经失调在新诊断和建立糖尿病是与脂肪组织炎症的标志.pdfVIP

Hindawi Publishing Corporation Experimental Diabetes Research Volume 2012, Article ID 878760, 8 pages doi:10.1155/2012/878760 Research Article Cardiac Autonomic Imbalance in Newly Diagnosed and Established Diabetes Is Associated with Markers of Adipose Tissue Inflammation David C. Lieb,1 Henri K. Parson,1 Gregg Mamikunian,2 and Aaron I. Vinik1 1 Division of Endocrinology and Metabolism, Department of Medicine, Eastern Virginia Medical School, Strelitz Diabetes Center for Endocrine and Metabolic Disorders, 855 West Brambleton Avenue, Norfolk, VA 23510, USA 2 Inter Science Institute, 944 West Hyde Park Boulevard, Inglewood, CA 90302, USA Correspondence should be addressed to Aaron I. Vinik, vinikai@ Received 19 July 2011; Accepted 7 September 2011 Academic Editor: Nicola Montano Copyright © 2012 David C. Lieb et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. Diabetics die from cardiovascular disease at a much greater rate than nondiabetics. Cardiac autonomic imbalance predicts increased cardiovascular risk and mortality. We studied the relationship between cardiac autonomic imbalance and adipose tissue-derived inflammation in newly diagnosed and established type 2 diabetes. Materials and Methods. Non-diabetics, newly diagnosed diabetics, and established diabetics were included. Anthropomorphic and biochemical measurements were obtained, and insulin resistance was approximated. Cardiac autonomic function was assessed using conventional measures and with power spectral analysis of heart rate. Results and Discussion. Heart rate variability was reduced in all diabetics. Interleuk