bone regeneration in artificial jaw cleft by use of carbonated hydroxyapatite particles and mesenchymal stem cells derived from iliac bone骨再生在人工下颌间隙利用碳酸羟基磷灰石粒子和间充质干细胞来源于髂骨头.pdfVIP

Hindawi Publishing Corporation International Journal of Dentistry Volume 2012, Article ID 352510, 8 pages doi:10.1155/2012/352510 Research Article Bone Regeneration in Artificial Jaw Cleft by Use of Carbonated Hydroxyapatite Particles and Mesenchymal Stem Cells Derived from Iliac Bone Motoko Yoshioka,1 Kotaro Tanimoto,1 Yuki Tanne,1 Keisuke Sumi,1 Tetsuya Awada,1 Nanae Oki,1 Masaru Sugiyama,2 Yukio Kato,3 and Kazuo Tanne1 1 Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan 2 Department of Oral Health Sciences, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan 3 Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan Correspondence should be addressed to Kotaro Tanimoto, tkotaro@hiroshima-u.ac.jp Received 2 December 2011; Revised 18 January 2012; Accepted 18 January 2012 Academic Editor: Chiaki Kitamura Copyright © 2012 Motoko Yoshioka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objectives of the Study. Cleft lip and palate (CLP) is a prevalent congenital anomaly in the orofacial region. Autogenous iliac bone grafting has been frequently employed for the closure of bone defects at the jaw cleft site. Since the related surgical procedures are quite invasive for patients, it is of great importance to develop a new less invasive technique. The aim of this study was to exam