cerebellar and hippocampal activation during eyeblink conditioning depends on the experimental paradigm a meg study小脑、海马活化期间眨眼条件取决于实验范式梅格的研究.pdfVIP

NEURAL PLASTICITY VOLUME 10, NO. 4, 2003 Cerebellar and HippocampalActivation during Eyeblink Conditioning Depends on the Experimental Paradigm: A MEG Study Peter Kirsch, 1’2 Caroline Achenbach,1’3 Martina Kirsch, Matthias Heinzmann,4 Anne Schienle1’2 and Dieter Vaitl ’2 l*Department ofClinical Physiological Psychology and2Bender Institute ofNeuroimaging, University ofGiessen, Germany; 3Departments ofNeurology and 4Psychology University ofHeidelberg, Germany SUMMARY KEYWORDS The cerebellum and the hippocampus are delay conditioning, trace conditioning, brain electric key structures for the acquisition of conditioned source analysis eyeblink responses. Whereas the cerebellum seems to be crucial for all types of eyeblink conditioning, the hippocampus appears to be involved only in complex types of learning. We INTRODUCTION conducted a differential conditioning study to explore the suitability of the design for Classical conditioning of eyeblink responses is magnetencephalography (MEG). In addition, one of the most frequently investigated paradigms. we compared cerebellar and hippocampal The experimental design consists of a tone or light activation during differential delay and trace as the conditioned stimulus (CS) and a corneal conditioning. Comparable conditioning effects airpuff as the unconditioned stimulus (US). Since were seen in both conditions, but a greater the occurrence of the conditioned response (CR) is resistance to extinction for trace condi