原创力文档can biofluids metabolic profiling help to improve healthcare during pregnancybiofluids代谢分析有助于提高孕期保健.pdfVIP
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can biofluids metabolic profiling help to improve healthcare during pregnancybiofluids代谢分析有助于提高孕期保健
Hindawi Publishing Corporation
Spectroscopy: An International Journal
Volume 27 (2012), Issue 5-6, Pages 515–523
doi:10.1155/2012/128367
Can Biofluids Metabolic Profiling Help to
Improve Healthcare during Pregnancy?
1 ´ 1 1 ´ 2 1
Gonc¸alo Grac¸a, Sılvia O. Diaz, Joana Pinto, Antonio S. Barros, Iola F. Duarte,
1 ´ 3 3 ´ 3
Brian J. Goodfellow, Eulalia Galhano, Cristina Pita, Maria do Ceu Almeida,
Isabel M. Carreira,4 and Ana M. Gil1
1 CICECO Department of Chemistry, University Campus of Santiago, University of Aveiro,
3810-193 Aveiro, Portugal
2 QOPNA Research Unit, Department of Chemistry, University Campus of Santiago,
University of Aveiro, 3810-193 Aveiro, Portugal
3 Maternidade Bissaya Barreto, Centro Hospitalar de Coimbra, 3000 Coimbra, Portugal
4 Cytogenetics and Genomics Laboratory, Faculty of Medicine, University of Coimbra and
Forensic Science Centre (CENCIFOR), Coimbra, Portugal
Correspondence should be addressed to Ana M. Gil, agil@ua.pt
Copyright © 2012 Gonc¸alo Grac¸a et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Abstract. This paper describes a metabonomics study of 2nd trimester biofluids (amniotic fluid, maternal urine, and blood
plasma), in an attempt to correlate biofluid metabolic changes with suspected/diagnosed fetal malformations (FM) and
chromosomal disorders as well as with later occurring gestational diabetes mellitus (GDM), preterm delivery (PTD), and
premature rupture of membranes (PROM). The global biochemical picture given by the threesome of bio
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