role of angiopoietin-2 in regulating growth and vascularity of astrocytomasangiopoietin-2的作用在调节生长和星形细胞瘤的血管.pdf

Hindawi Publishing Corporation Journal of Oncology Volume 2010, Article ID 659231, 7 pages doi:10.1155/2010/659231 Research Article Role of Angiopoietin-2 in Regulating Growth and Vascularity of Astrocytomas Gelareh Zadeh,1 Keyvan Koushan,1 Qian Baoping,1 Patrick Shannon,2 and Abhijit Guha1, 3 1Arthur Sonia Labatts Brain Tumor Center, Hospital for Sick Children, University of Toronto, Toronto, Canada M5G 2G4 2 Department of Pathology, Western Hospital, University of Toronto, Toronto, Canada M5G 2G4 3 Division of Neurosurgery, Western Hospital, University of Toronto, Toronto, Canada M5G 2G4 Correspondence should be addressed to Gelareh Zadeh, gelareh.zadeh@uhn.on.ca Received 13 December 2009; Accepted 15 February 2010 Academic Editor: Arkadiusz Dudek Copyright © 2010 Gelareh Zadeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Angiopoietins and Tie2 are angiogenic-specific ligand and receptor complex that have been shown to play a critical role in tumor angiogenesis. Angiopoietin-2 (Ang2) is one of four ligands for receptor Tie2 and it is the naturally occurring antagonist to Tie2, inhibiting the action of Angiopoietin-1 (Ang1). Over the last decade, significant research has focused on elucidating the role of Ang2 in cancer biology and its exact role in tumor angiogenesis remains elusive. In this study we have focused on establishing the role of Ang2 in angiogenesis of malignant astrocytomas. We have demonstrated that Ang2 significantly enhances the vascular growth of malignant astrocytomas and constant upregulation of Ang2 throughout all phases of tumor growth generates abnormal vascular structures t