role of hla in hematopoietic stem cell transplantationhla在造血干细胞移植中的作用.pdf

Hindawi Publishing Corporation Bone Marrow Research Volume 2012, Article ID 680841, 7 pages doi:10.1155/2012/680841 Review Article Role of HLA in Hematopoietic Stem Cell Transplantation Meerim Park1 and Jong Jin Seo2 1 Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea 2 Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, Republic of Korea Correspondence should be addressed to Jong Jin Seo, jjseo@amc.seoul.kr Received 27 July 2012; Accepted 3 September 2012 Academic Editor: Andrzej Lange Copyright © 2012 M. Park and J. J. Seo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The selection of hematopoietic stem cell transplantation (HSCT) donors includes a rigorous assessment of the availability and human leukocyte antigen (HLA) match status of donors. HLA plays a critical role in HSCT, but its involvement in HSCT is constantly in flux because of changing technologies and variations in clinical transplantation results. The increased availability of HSCT through the use of HLA-mismatched related and unrelated donors is feasible with a more complete understanding of permissible HLA mismatches and the role of killer-cell immunoglobulin-like receptor (KIR) genes in HSCT. The influence of nongenetic factors on the tolerability of HLA mismatching has recently become evident, demonstrating a need for the integration of both genetic and nongenetic variables in donor selection. 1. Introduction 2. HLA Typing Allogeneic hematopoietic