role of killer immunoglobulin-like receptor and ligand matching in donor selection杀手的角色immunoglobulin-like受体和配体在捐赠者选择匹配.pdf

Hindawi Publishing Corporation Bone Marrow Research Volume 2012, Article ID 271695, 6 pages doi:10.1155/2012/271695 Review Article Role of Killer Immunoglobulin-Like Receptor and Ligand Matching in Donor Selection Meral Beksac¸1, 2 and Klara Dalva3 1 Department of Hematology, Ankara University Unrelated Donor Registry and Cord Blood Bank, Ankara, Turkey 2 Ankara Tip Fakultesi Hematoloji Bilim Dali, Cebeci Yerleskesi, Dikimevi, 06620 Ankara, Turkey 3 ˙ HLA Typing Laboratories, Department of Hematology, Ankara University School of Medicine, Ibni Sina Hospital, Sihhiye, 06100 Ankara, Turkey Correspondence should be addressed to Meral Beksac¸, meral.beksac@.tr Received 16 August 2012; Accepted 1 October 2012 Academic Editor: Andrzej Lange Copyright © 2012 M. Beksac¸ and K. Dalva. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Despite all efforts to improve HLA typing and immunosuppression, it is still impossible to prevent severe graft versus host disease (GVHD) which can be fatal. GVHD is not always associated with graft versus malignancy and can prevent stem cell transplantation from reaching its goals. Overall T-cell alloreactivity is not the sole mechanism modulating the immune defense. Innate immune system has its own antigens, ligands, and mediators. The bridge between HLA and natural killer (NK) cell-mediated reactions is becoming better understood in the context of stem cell transplantation. Killer immunoglobulin-like receptors (KIRs) constitute a wide range of allele