serum chlorine level as a possible predictive factor for oxaliplatin-induced peripheral neuropathy血清氯水平作为一个可能的预测因素oxaliplatin-induced周围神经病变.pdf

Pharmacology Pharmacy, 2012, 3, 44-51 /10.4236/pp.2012.31007 Published Online January 2012 (http://www.SciRP.org/journal/pp) Serum Chlorine Level as a Possible Predictive Factor for * Oxaliplatin-Induced Peripheral Neuropathy 1,2 1 1 1 3 1 Satoshi Tanaka , Naoto Suzuki , Akira Mimura , Maho Kurosawa , Yuriko Murai , Daisuke Saigusa , Makio Gamoh4 2 1,5 , Masuo Sato , Yoshihisa Tomioka 1Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 2 3 Japan; Department of Pharmacy, South Miyagi Medical Center, Ohgawara, Japan; Pharmacy Education and Research Center, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan; 4Department of Medical Oncology, South Miyagi Medical Center, Ohgawara, Japan; 5Department of Community Pharmacy, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. Email: ytomioka@m.tohoku.ac.jp Received September 24th, 2011; revised November 27th, 2011; accepted December 9th, 2011 ABSTRACT Peripheral neuropathy is a major adverse event associated with oxaliplatin-based chemotherapy and is a major dose-limiting adverse event in clinical practice. However, some patients treated with oxaliplatin may show no or mini- mal peripheral neuropathy. These differences are still poorly understood. The data on patients with colorectal cancer who received oxaliplatin-based regimens between January 2005 and June 2010 at South Miyagi Medica