serum cytokine levels and t lymphocyte subsets in pregnant women with eclampsia血清细胞因子水平和t淋巴细胞亚群与子痫孕妇.pdf

Vol.2, No.3, 116-124 (2012) Open Journal of Immunology /10.4236/oji.2012.23014 Serum cytokine levels and T lymphocyte subsets in pregnant women with eclampsia 1* 1 2 Bolanle O. P. Musa , Geoffrey C. Onyemelukwe , Olubunmi A. Olatunji , Kingsley O. Odogwu2 3 4 , Joseph O. Hambolu , Terfa S. Kene 1Immunology Unit, Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria; * Corresponding Author: bolamusa2002@ 2Department of Obstetrics and Gynaecology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria 3Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria 4Community Medicine Department, Ahmadu Bello University, Zaria, Nigeria Received 19 April 2012; revised 17 May 2012; accepted 28 May 2012 ABSTRACT T cells were further decreased in eclampsia and pregnant controls compared to nonpregnant Background: Eclampsia, defined as the occur- controls (p 0.05). A decreasing CD4/CD8 ratio rence during pregnancy of hypertension, oe- was observed from non-pregnant to pregnant dema, proteinuria and/or other neurologic ab- controls and to patients with eclampsia but- normalities, causes substantial morbidity and tressing an increase