serum endothelin-1 and transforming growth factor- levels in the newborns with respiratory distress血清endothelin-1和转化生长因子水平与新生儿呼吸窘迫.pdf

Hindawi Publishing Corporation Mediators of Inflammation Volume 2006, Article ID 85432, Pages 1–5 DOI 10.1155/MI/2006/85432 Research Communication Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress Derya Benzer,1 A. Denizmen Aygun,1 Ahmet Godekmerdan,2 A. Nese (Citak) Kurt,1 Saadet Akarsu,1 and Erdal Yilmaz1 1 Department of Pediatrics, Firat University Medical Faculty, Elazig 23119, Turkey 2 Department of Immunology, Firat University Medical Faculty, Elazig 23119, Turkey Received 6 March 2006; Revised 3 July 2006; Accepted 4 July 2006 The purpose of this present study was to evaluate the serum levels of ET-1 and TGF-β in the newborns with respiratory distress. In this study, newborns with respiratory distress hospitalized into the Newborn Intensive Care Unit were included. The highest values of ET-1 and TGF-β were obtained from newborns with diagnosis as meconium aspiration syndrome (5.70 ± 5.87 pg/mL and 3.75 ± 1.94 pg/mL, resp) in the sample obtained in the first six hours after birth, and these are statistically different from control group (P .05). Also, same results were obtained for newborns with respiratory distress syndrome (3.37 ± 1.59 pg/mL and 2.05 ± 0.98 pg/mL, resp). After oxygen treatment, ET-1 values obtained in the first six hours of life were decreased regularly in the following days (P .05). In the differentiating diagnosis of the respiratory distress of newborns, the investigation of ET-1 and TGF-β levels is meaningful. The ET-1 levels investigated in the first six hours is more useful in determining the prognosis, and repeating ET-1 levels in the following days is more meaningful to determine clinical response. Copyright © 2006 Derya Benzer et al. This is an open access article distributed under the Creative Commons Att