serum il-1β, sil-2r, il-6, il-8 and tnf-α in schizophrenic patients, relation with symptomatology and responsiveness to risperidone treatment血清il-1βsil-2r,il - 6,引发和tnf-α在精神分裂症患者中,与利培酮治疗的症状和响应性.pdf

Research Paper Mediators of Inflammation, 10, 109– 115 (2001) ACT IVAT IO N of the inflammatory response system and Serum IL-1b , sIL-2R, IL-6, IL-8 and varied levels of cytokines in acute schizophrenia have been suggested by recent studies. Psychopharmaco- TNF-a in schizophrenic patients, logic agents can differentially effect cytokine produc- relation with symptomatology and tion, which suggests that therapeutic function of neuroleptics may involve immunomodulation. responsiveness to risperidone The present study was carried out to examine: (i) serum concentrations of interleukin (IL)-1b , soluble treatment interleukin-2 receptor (sIL-2R), IL-6, IL-8 and tumour necrosis factor (TNF)-a in schizophrenic patients; (ii) their relation with psychopathological assessment; Ayçsec Binnur ErbagciÆ CA , Hasan Herken, and (iii) the relation of the initial cytokine levels with responsiveness to risperidone therapy. Oya Koyl¨ uoglu,¨ Necat Yilmaz and Thirty-four drug-free schizophrenic patients with Mehmet Tarakçioglu acute exacerbation and 23 age- and gender-matched healthy controls were recruited for this study. Psy- chopathological assessments at admission and Department of Biochemistry and Clinical throughout risperidone treatment for 60 days were Biochemistry, Faculty of Medicine, University of recorded. Serum cytokine concentrations were deter- Gaziantep, TR-27310 Gaziantep, Turkey mined with chemilumunescence assays. According to our results, serum IL-1b , sIL-2R, IL-6, IL-8 and TNF-a concentrations adjusted for age, gender, body mass index and smoking were no CA Corresponding Author diff