serum levels of gelatinase associated lipocalin as indicator of the inflammatory status in coronary artery disease血清水平的白明胶酶相关lipocalin作为炎症状态的指示器在冠状动脉疾病.pdf

Hindawi Publishing Corporation International Journal of Inflammation Volume 2012, Article ID 189797, 8 pages doi:10.1155/2012/189797 Clinical Study Serum Levels of Gelatinase Associated Lipocalin as Indicator of the Inflammatory Status in Coronary Artery Disease Nikolaos Kafkas,1 Christos Demponeras,1 Filitsa Zoubouloglou,2 Loukia Spanou,2 Dimitrios Babalis,1 and Konstantinos Makris2 1 Cardiology Department, KAT General Hospital, Athens, Greece 2 Clinical Biochemistry Department, KAT General Hospital, Athens, Greece Correspondence should be addressed to Nikolaos Kafkas, kafkasncard@yahoo.gr Received 3 March 2012; Accepted 13 July 2012 Academic Editor: Masanori Aikawa Copyright © 2012 Nikolaos Kafkas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Atherosclerosis is a chronic inflammatory disease and the acute clinical manifestations represent acute on chronic inflammation. Neutrophil gelatinase-associated lipocalin (NGAL) is found in the granules of human neutrophils, with many diverse functions. The aim of this study was to evaluate the hypothesis that levels NGAL in blood may reflect the inflammatory process in various stages of coronary artery disease. Methods. We studied 140 patients, with SA 40, UA 35, NSTEMI 40, and STEMI 25, and 20 healthy controls. Serum NGAL was measured upon admission and before coronary angiography. Results. Significant dif- ferences were observed in median serum-NGAL(ng/mL) between patients with SA (79.23 (IQR, 37.50–100.32)), when compared with UA (108.00 (68.34–177.59)), NSTEMI (166.49 (109.24–247.20)), and STEMI (178.63 (111.18–305.92)) pa