serum levels of tnf-α, sil-2r, il-6, and il-8 are increased and associated with elevated lipid peroxidation in patients with beh？ets disease血清水平的tnf-α,sil-2r、il - 6和引发与高脂质过氧化增加,相关患者的本·等的疾病.pdf

Research Communication Mediators of Inflammation, 11, 87–93 (2002) AIM: Behçet’s disease (BD) is a systemic immuno- Serum levels of TNF-a , sIL-2R, IL-6, inflammatory disorder and the aetiopathogenesis is to be specified. Cytokines play a role in immune and IL-8 are increased and response and in many inflammatory diseases. The associated with elevated lipid aim of this case– control study is to investigate serum pro-inflammatory cytokine tumour necrosis factor peroxidation in patients with (TNF)-a , interleukin-1beta (IL-1b ), soluble IL-2 recep- tor (sIL-2R), IL-6, and chemokine IL-8 levels in Behçet’s disease patients with BD. We also determined the end product of lipid peroxidation (malondialdehyde (MDA)) in BD patients as an index for oxidative stress. 1,CA 2 2 Cem Evereklioglu , Hamdi Er , Yusuf Turk¨ oz¨ and Methods: A total of 37 patients (19 men, 18 women) 1 Mustafa Cekmen with BD (active, n = 17; inactive, n = 20) and 20 age- l matched and sex-matched healthy control subjects (11 men, nine women) included in this cross-sec- tional, blinded study. Serum TNF-a , IL-1b , sIL-2R, IL-6 1Department of Ophthalmology, Gaziantep and IL-8 levels were determined by a spectrophot- University Medical Faculty, Research Hospital, ometer technique using the immulite chemilumines- Gaziantep Turkey; and 2Department of Biochemistry, cent immunometric assay. Lipid peroxidation was Inon¨ u¨ University Medical Faculty, Turgut Ozal evaluated by Wasowicz et al. The levels of