serum neopterin is not increased in obese juveniles血清neopterin不增加肥胖的青少年.pdf

Hindawi Publishing Corporation Journal of Obesity Volume 2011, Article ID 946795, 7 pages doi:10.1155/2011/946795 Research Article Serum Neopterin Is Not Increased in Obese Juveniles Harald Mangge,1 Florian Freytag,1 Gunter Almer,1 Daniel Weghuber,2 Carmen Bauer-Denk,1 and Dietmar Fuchs3 1 Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria 2 Department of Pediatrics, University Hospital of Salzburg, 5020 Salzburg, Austria 3 Division of Biological Chemistry, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria Correspondence should be addressed to Harald Mangge, harald.mangge@meduni-graz.at Received 11 June 2010; Accepted 22 December 2010 Academic Editor: A. Halpern Copyright © 2011 Harald Mangge et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. Cardiovascular disease is associated with inflammation and immune activation, concentrations of immune activation markers like neopterin predict outcome in adults. Methods. Serum neopterin concentrations and early metabolic and pre- atherosclerotic symptoms were analyzed in 295 obese juveniles and 101 normal weight controls of similar age. Additionally, the influence of a 12 months weight reduction program on neopterin levels was investigated in 31 obese juveniles. Results. Intima- media thickness of common carotid arteries (IMT) and the concentrations of C-reactive protein (CRP) were increased in the obese juveniles (P .001). Also triglycerides, oxidized LDL, fasted insulin levels, HOMA-index, leptin, liver transaminases and