serum tnf-alpha level predicts nonproliferative diabetic retinopathy in children儿童的血清tnf水平预测nonproliferative糖尿病性视网膜病变.pdf

Hindawi Publishing Corporation Mediators of Inflammation Volume 2007, Article ID 92196, 5 pages doi:10.1155/2007/92196 Clinical Study Serum TNF-Alpha Level Predicts Nonproliferative Diabetic Retinopathy in Children 1 ´ 1 ´ 2 2 1 Katarzyna Zorena, Jolanta Mysliwska, Małgorzata Mysliwiec, Anna Balcerska, Łukasz Hak, 3 ´ 3 Paweł Lipowski, and Krystyna Raczynska 1 Department of Immunology, Medical University of Gdansk, De¸binki 1, 80-210 Gdansk, Poland ´ ´ 2 Diabetological Department, Clinic of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdansk, ´ 80-210 Gdansk, Poland ´ 3 Department and Clinic of Ophthalmology, Medical University of Gdansk, 80-210 Gdansk, Poland ´ ´ Received 16 November 2006; Revised 28 February 2007; Accepted 1 March 2007 The aim of this study was identification of the immunologic markers of the damage to the eye apparatus at early stages of dia- betes mellitus (DM) type 1 children. One hundred and eleven children with DM type 1 were divided into two groups: those with nonproliferative diabetic retinopathy (NPDR) and without retinopathy. All the children had their daily urine albumin excretion, HbA1c, C-peptide measured, 24-hour blood pressure monitoring, and ophthalmologic examination. Levels of TNF-α, IL-6,