sex- and age-related differences in bone microarchitecture in men relative to women assessed by high-resolution peripheral quantitative computed tomography性别和年龄差异男性相对于女性的骨微体系结构评估高分辨率外围定量计算机断层扫描.pdf

Hindawi Publishing Corporation Journal of Osteoporosis Volume 2012, Article ID 129760, 6 pages doi:10.1155/2012/129760 Research Article Sex- and Age-Related Differences in Bone Microarchitecture in Men Relative to Women Assessed by High-Resolution Peripheral Quantitative Computed Tomography Shreyasee Amin1, 2 and Sundeep Khosla3 1 Division of Rheumatology, Department of Internal Medicine, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA 2 Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Internal Medicine, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA 3 Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA Correspondence should be addressed to Shreyasee Amin, amin.shreyasee@ Received 5 September 2011; Accepted 31 October 2011 Academic Editor: Pawel Szulc Copyright © 2012 S. Amin and S. Khosla. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The trabecular and cortical compartments of bone each contributes to bone strength. Until recently, assessment of trabecular and cortical microstructure has required a bone biopsy. Now, trabecular and cortical microstructure of peripheral bone sites can be determined noninvasively using high-resolution peripheral quantitative computed tomography (HR-pQCT). Studies that have used HR-pQCT to evaluate cohorts of both men and women have provided novel insights into the changes in bone microarchitecture that occur with age between the sex