sickle cell disease and pregnancy does outcome depend on genotype or phenotype镰状细胞病和怀孕的结果取决于基因型和表现型.pdfVIP

International Journal of Clinical Medicine, 2011, 2, 313-317 313 doi:10.4236/ijcm.2011.23054 Published Online July 2011 (http://www.SciRP.org/journal/ijcm) Sickle Cell Disease and Pregnancy: Does Outcome Depend on Genotype or Phenotype? 1 1 1 2 1 Catherine Berzolla , Neil Stuart Seligman , Aisha Nnoli , Kevin Dysart , Jason K. Baxter , Samir K. Ballas3 1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Philadelphia, USA; 2Division of Neonatol- ogy/Nemours Foundation, Department of Pediatrics, Philadelphia, USA; 3Division of Hematology/Cardeza Foundation, Department of Internal Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, USA. Email: cberzolla@ Received February 25th, 2011; revised May 4th, 2011; accepted June 11th, 2011. ABSTRACT Objective: Women with sickle cell disease (SCD) who become pregnant are at risk for serious maternal and fetal com- plications. Our objective was to determine if pr egnancy outcome is dependent on phenotype. Methods : Retrospective cohort study of pregnant women with SCD, including hemoglobin (Hb) SS, Hb SC and Hb Sβ-thalassemia, between January 1999 and December 2008. Antenatal and neonatal outcomes were compared between pregnancies with painful episodes and those without. The primary outcome was preterm birth (PTB) 37 weeks. Secondary outcomes included maternal medical complications, antenatal complications, delivery outcomes and neonatal outcomes. Results : 31 women were included (18 (58%) with painful episodes, 13 (42%) without painful episodes). The median number of painful episodes was 2.5 (1 - 19) and these women required a median of 13 total days (1 - 59) of inpatient tr