splicing programs and cancer拼接程序和癌症.pdf

Hindawi Publishing Corporation Journal of Nucleic Acids Volume 2012, Article ID 269570, 9 pages doi:10.1155/2012/269570 Review Article Splicing Programs and Cancer Sophie Germann,1, 2, 3, 4 Lise Gratadou,1, 2, 3, 4 Martin Dutertre,1, 2, 3, 4 and Didier Auboeuf1, 2, 3, 4 1 Universite de Lyon, 28 rue Laennec, 69008 Lyon, France ´ ¨ 2 Inserm U1052, 28 rue Laennec, 69008 Lyon, France ¨ 3 CNRS UMR5286, 28 rue Laennec, 69008 Lyon, France ¨ 4 Centre de Recherche en Cancerologie de Lyon, Centre Leon Berard, 28 Rue Laennec, 69008 Lyon, France ´ ´ ´ ¨ Correspondence should be addressed to Didier Auboeuf, didier.auboeuf@inserm.fr Received 26 July 2011; Accepted 23 August 2011 Academic Editor: Juan Valcarcel Copyright © 2012 Sophie Germann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Numerous studies report splicing alterations in a multitude of cancers by using gene-by-gene analysis. However, understanding of the role of alternative splicing in cancer is now reaching a new level, thanks to the use of novel technologies allowing the analysis of splicing at a large-scale level. Genome-wide analyses of alternative splicing indicate that splicing alterations can affect the products of gene networks involved in key cellular programs. In addition, many splicing variants identified as being misregulated in cancer are expressed in normal tissues. These observations suggest that splicing progr