呼吸系统深部真菌感染耐药分析.doc

呼吸系统深部真菌感染耐药分析[摘要] 目的:了解呼吸系统真菌感染耐药率的变化,为预防其感染和临床合理用药提供依据。方法:回顾性分析我院呼吸科2006～2008年真菌感染的特点,监测177例真菌的药敏结果。结果:2006～2008年真菌感染例数分别为46例、64例、67例,其中白色念珠菌98例,占55.4%。2006～2008年白色念珠菌对氟康唑、伊曲康唑、益康唑的耐药率均为0;光滑念珠菌对氟康唑的耐药率分别为0、11.1%、22.2%;光滑念珠菌对伊曲康唑的耐药率分别为9.1%、0、15.8%。结论:呼吸科真菌感染的患者在逐年增加,白色念珠菌为真菌感染的主要菌种。 [关键词] 真菌感染;耐药性;呼吸系统 [中图分类号] R519[文献标识码]A [文章编号]1673-7210(2010)01(b)-019-03 Drug resistance analysis on fungus infection in respiratory system GAO Miaoping1, HUANG Yu’e1, YUAN Min2 (1.Department of Pharmacy, the Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China;2.Department of Laboratory, the Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China) [Abstract] Objective: To investigate the change of resistance rate of fungus infection in respiratory system, in order to provide essential basis for preventing and treating it. Methods: From 2006 to 2008 in our hospital, the clinical characteristics of fungus infection in respiratory department were retrospectively analyzed, the results of 177 cases of fungal drug susceptibility were monitored. Results: From 2006 to 2008 the number of cases of fungal infection were 46 cases, 64 cases, 67 cases, of which 98 cases of Candida albicans, accounting for 55.4%. From 2006 to 2008, the resistance rates of Candida albicans to Fluconazole, Itraconazole, Econazole were 0; the resistance rates of Candida glabrata to Fluconazole rates were 0, 11.1%, 22.2%; and the resistance rates of Candida glabrata to Itraconazole were 9.1%, 0, 15.8%. Conclusion: Respiratory fungal infections in patients increases every year, Candida albicans is the major fungal infection bacteria. [Key words] Fungus infection; Drug resistance; Respiratory system 抗生素、糖皮质激素的广泛使用,以及气管插管,呼吸机等有创操作的广泛开展,呼吸系统深部真菌感染患者逐年增加[1]。深部真菌感染的死亡率很高,即使救治成功也花费巨大[2]。而且由于真菌感染临床表现缺乏特异性;培养阳性率不高,培养周期长,给及时准确诊断治疗带来很大困难[3]。为了解真菌感染的特点和近年来真菌耐药状况,对我院呼吸科2006～2008年共177例真菌感染情况作出初步分析。 1 材料和方法 1.1 病例资料 2006～2008年我院呼吸科住院患者采集的痰、血液、尿、粪便、胸腹