慢性非细菌性前列腺炎患者前列腺液TNF-α、IL-8检测及临床意义.docVIP

慢性非细菌性前列腺炎患者前列腺液TNF-α、IL-8检测及临床意义[摘要] 目的：探讨前列腺按摩液（EPS）中细胞因子白细胞介素-8（IL-8）及肿瘤坏死因子-α（TNF-α）在Ⅲ型前列腺炎[慢性非细菌性前列腺炎/慢性盆底疼痛综合征（CAP/CPPS）]诊断、分型中的意义。方法：ELISA法检测50例临床诊断为Ⅲ型前列腺炎患者EPS中IL-8及TNF-α水平。结果：慢性非细菌性前列腺炎EPS中ⅢA型组TNF-α水平与ⅢB型组、对照组比较，有显著性差异（P＜0.05）；ⅢB型组TNF-α水平与对照组比较，无显著性差异（P＞0.05）。ⅢA型组IL-8水平与ⅢB型组、对照组比较，有非常显著性差异（P＜0.01）；ⅢB型组与对照组比较，有非常显著性差异（P＜0.01）。所有患者EPS中TNF-α水平与WBC计数无明显相关性（r=-0.167，P＞0.05），IL-8水平与WBC计数的相关性分析显示呈正相关（r=0.836，P＜0.01）。结论：检测Ⅲ型前列腺炎患者EPS中IL-8及TNF-α水平可能有助于Ⅲ型前列腺炎的分型诊断，并可作为了解病情和评价治疗效果的一个有价值的指标。 [关键词] IL-8；TNF-α；慢性非细菌性前列腺炎 [中图分类号] R697+.33[文献标识码]A [文章编号]1673-7210（2009）05（b）-022-03 Detection and clinical significance of TNF-α and IL-8 in EPS of patients with chronic nonbacterial prostatitis HUANG Zhihong, YUAN Shaoying, QIN Zhan, LI Shenguo, ZHANG Zhaolei (Zhuhai Hospital of Guangdong Provincial TCM Affiliated Hospital of Guangzhou University of Chinese Medicine, Zhuhai 519015, China) [Abstract] Objective: To investigate the significance of interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) in expressed prostatic secretion (EPS) for diagnosis and classification of prostatitis Ⅲ [chronic nonbacterial prostatitis/chronic pelvic pain syndrome (CPPS)]. Methods: IL-8 and TNF-α in EPS of 50 patients with prostatitis Ⅲ were detected by ELISA. Results: The level of TNF-α in EPS of patients with chronic nonbacterial prostatitis group ⅢA was significantly different with group ⅢB and the control group (P＜0.05). Level of TNF-α had no statistical significance between group ⅢB and the control group (P＞0.05). Level of IL-8 in group ⅢA had very significant difference compared with group ⅢB and the control group (P＜0.01);compared with the control group, IL-8 in group ⅢB had a very significant difference (P＜0.01). TNF-α level in EPS of all patients had no significant correlation with WBC count (r=-0.167, P＞0.05), IL-8 level and WBC count showed a positive correlation by the correlation analysis (r=0.836, P＜0.01). Conclusion: The detection of IL-8 and TNF-α levels in p