米索前列醇肛入联合催产素穴位注射用于预防产后出血临床分析.docVIP

米索前列醇肛入联合催产素穴位注射用于预防产后出血临床分析[摘要] 目的：观察米索前列醇联合催产素不同给药途径用于预防产后出血的临床效果。方法：选择我院2006年1月～2009年1月足月正常妊娠阴道分娩产妇300例，随机分为A组和B组，A组：米索前列醇舌下含化联合催产素静脉注射组100例，B组：米索前列醇肛入联合催产素穴位注射组100例，C组：单用催产素静脉用药组100例。观察三组产妇第三产程时间、产后2 h的出血量及不良反应。结果：A和B两组联合用药较C组在缩短第三产程时间、减少产后出血量方面均有显著改善，差异有统计学意义（P＜0.05），A组较B组在缩短第三产程时间、减少产后出血量方面均有改善，且恶心、呕吐、腹泻、发热、寒战等副作用均明显减少，差异有统计学意义（P＜0.05）。结论：米索前列醇联合催产素在预防产后出血中较单一应用催产素效果好，且米索前列醇肛入联合催产素穴位注射较米索前列醇舌下含化联合催产素静脉注射效果好，且用药方便、安全，起效快，不良反应少，值得临床推广。 [关键词] 米索前列醇 催产素 产后出血 预防 [中图分类号] R714.461[文献标识码]B [文章编号]1673-7210（2011）02（c）-063－０2 Clinical analysis on Misoprostol rectal administration and Oxytocin point injection for prevention of postpartum hemorrhage WU Yanping (Department of Gynaecology and Obstetrics, Traditional Chinese Medical Hospital of Penglai City, Penglai 265600, China) [Abstract] Objective: To assess the effecacy and side effects of 400 microg of Misoprostol rectal administration combined with Oxytocin point injection compared with an intravenous infusion of 10 IU of Oxytocin as prophylaxis against postpartum hemorrhage (PPH). Methods: A total of 300 cases in labor were randomized into three groups (100 cases in each). Before or within 1 minute of delivery of the fetal head participants in group 1 received Oxytocin point injection 10 IU and Misoprostol rectal administration after delivery of the fetal; group 2 received sublingual 400 microg misoprostol and 10 IU of Oxytocin intravenously; group 3 received 20 IU of Oxytocin intravenously. Results: Group 1 and 2 were more useful than group 3 for prevention of postpartum hemorrhage; rather, group 1 had fewer side effects than others. Conclusion: Routine use of Oxytocin point injection 10 IU and 400 microg of Misoprostol rectal administration is effective in reducing blood loss after delivery. [Key words] Misoprostol; Oxytocin; Postpartum hemorrhage; Prevention 产后出血（postpartum hemorrhage， PPH）是产科最严重的并发症之一，是导致我国孕产妇死亡的首位原因，严重威胁产妇生命安全[1]。产后出血一旦发生，严重威胁孕产妇的生命安全，且基层单位抢救措施不力，导致因产后出血死亡的病例居高不下，故防重于治。我院自