antidepressant response in major depressive disorder a meta-regression comparison of randomized controlled trials and observational studies抗抑郁药的反应重度抑郁症多元回归比较的随机对照试验和观察性研究.pdfVIP

Antidepressant Response in Major Depressive Disorder: A Meta-Regression Comparison of Randomized Controlled Trials and Observational Studies 1,2,3 ` 1,4 1,5,6 Florian Naudet *, Anne Solene Maria , Bruno Falissard ´ ´ ´ ´ 1 Institut National de la Sante Et de la Recherche Medicale U669, Paris, France, 2 Universite de Rennes 1, Unite de Recherche Universitaire EM-425 Behavior and Basal ´ Ganglia, Rennes, France, 3 Centre Hospitalier Guillaume Regnier, Service Hospitalo-Universitaire de Psychiatrie, Rennes, France, 4 Ecole de Psychologues Praticiens, Paris, ´ ´ ´ ˆ ˆ France, 5 Universite Paris-Sud and Universite Paris Descartes, Unite Mixte de Recherche S0669, Paris, France, 6 Assistance Publique Hopitaux de Paris, Hopital Paul Brousse, ´ ´ Departement de sante publique, Villejuif, France Abstract Background: To compare response to antidepressants between randomized controlled trials (RCTs) and observational trials. Methods and Findings: Published and unpublished studies (from 1989 to 2009) were searched for by 2 reviewers on Medline, the Cochrane library, Embase, , Current Controlled Trial, bibliographies and by mailing key organisations and researchers. RCTs and observational studies on fluoxetine or venlafaxine in first-line treatment for major depressive disorder reported in English, French or Spanish language were included