antidepressant treatment normalizes white matter volume in patients with major depression抗抑郁药物治疗规范化白质体积在抑郁症患者.pdfVIP

Antidepressant Treatment Normalizes White Matter Volume in Patients with Major Depression 1. 2. 1 1 3 1 Ling-Li Zeng , Li Liu , Yadong Liu , Hui Shen , Yaming Li *, Dewen Hu * 1 College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, People’s Republic of China, 2 Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, People’s Republic of China, 3 Department of Nuclear Medicine, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, People’s Republic of China Abstract Objective: To investigate white matter volume abnormalities in patients with major depression and the effects of antidepressant treatment on white matter volume. ¨ Method: Magnetic resonance imaging (MRI) was performed on 32 treatment-naıve depressed patients, 17 recovered patients who had received antidepressant treatment and subsequently achieved clinical recovery and 34 matched controls. ¨ Results: Relative to the healthy controls, the treatment-naıve depressed patients showed increased white matter volumes in the left dorsolateral prefrontal cortex (DLPFC) and left putamen and reduced white matter volumes in the left cerebellum ¨ posterior lobe and left inferior parietal lobule. For the treatment-naıve patients, the length in mon