basal lat-diacylglycerol-rasgrp1 signals in t cells maintain tcrα gene expression在t细胞基底lat-diacylglycerol-rasgrp1信号保持tcrα基因表达.pdfVIP

Basal LAT-diacylglycerol-RasGRP1 Signals in T Cells Maintain TCRa Gene Expression 1. 1. 2 2 3,4,5 Evan Markegard , Evan Trager , Chih-wen Ou Yang , Weiguo Zhang , Arthur Weiss , Jeroen P. Roose1* 1 Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America, 2 Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America, 3 Department of Medicine, University of California San Francisco, San Francisco, California, United States of America, 4 Department of Microbiology and Immunology and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America, 5 Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, California, United States of America Abstract In contrast to the well-characterized T cell receptor (TCR) signaling pathways that induce genes that drive T cell ¨ development or polarization of naıve CD4 T cells into the diverse T 1, T 2, T 17 and T lineages, it is unclear what signals H H H reg maintain specific gene expression in mature resting T cells. Resting T cells residing in peripheral lymphoid organs exhibit low-level constitutive signaling. Whereas tonic signals in B cells are known to be critical for survival, the roles of tonic signals in peripheral T cells are unknown. Here we demonstrate that constitutive signals in Jurkat T cell lines are transduced via the ad