baseline levels of influenza-specific cd4 memory t-cells affect t-cell responses to influenza vaccines基线水平的流感特定cd4记忆t细胞影响t细胞对流感疫苗的反应.pdfVIP

Baseline Levels of Influenza-Specific CD4 Memory T-Cells Affect T-Cell Responses to Influenza Vaccines 1,2. 3. 1,2 1,2¤ 4 Xiao-Song He *, Tyson H. Holmes , Sanae Sasaki , Maria C. Jaimes , George W. Kemble , Cornelia L. Dekker5, Ann M. Arvin5,6, Harry B. Greenberg1,2,6 1 Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America, 2 VA Palo Alto Health Care System, Palo Alto, California, United States of America, 3 Department of Health Research and Policy (Biostatistics), Stanford University School of Medicine, Stanford, California, United States of America, 4 MedImmune Vaccines, Mountain View, California, United States of America, 5 Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America, 6 Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America Abstract Background: Factors affecting immune responses to influenza vaccines have not been studied systematically. We hypothesized that T-cell and antibody responses to the vaccines are functions of pre-existing host immunity against influenza antigens. Methodology/Principal Findings: During the 2004 and 2005 influenza seasons, we have collected data on cellular and humoral immune reactivity to influenza virus in blood samples collected before and after immunization with inactivated or live attenuated influenza vaccines in healthy children and adults. We first used cross-validated lasso regression on the 2004 dataset to identify a group of candidate baseline correlates with T-cell and antibody responses to vaccines, d