bordetella pertussis infection or vaccination substantially protects mice against b. bronchiseptica infection百日咳博德特氏菌感染或疫苗接种大大能保护小鼠免受b bronchiseptica感染.pdfVIP

Bordetella pertussis Infection or Vaccination Substantially Protects Mice against B. bronchiseptica Infection 1,2 1,3 1 Elizabeth M. Goebel , Xuqing Zhang , Eric T. Harvill * 1 Department of Veterinary and Biomedical Sciences, the Pennsylvania State University, University Park, Pennsylvania, United States of America, 2 Graduate Program in Immunology and Infectious Diseases, the Pennsylvania State University, University Park, Pennsylvania, United States of America, 3 Graduate Program in Genetics, the Pennsylvania State University, University Park, Pennsylvania, United States of America Abstract Although B. bronchiseptica efficiently infects a wide range of mammalian hosts and efficiently spreads among them, it is rarely observed in humans. In contrast to the many other hosts of B. bronchiseptica, humans are host to the apparently specialized pathogen B. pertussis, the great majority having immunity due to vaccination, infection or both. Here we explore whether immunity to B. pertussis protects against B. bronchiseptica infection. In a murine model, either infection or vaccination with B. pertussis induced antibodies that recognized antigens of B. bronchiseptica and protected the lower ¨ respiratory tract of mice against three phylogenetically disparate strains of B. bronchiseptica that efficiently infect naıve animals. Furthermore, vaccination with purified B. pertussis-derived pertactin, filamentous hemagglutinin or the human acellular vaccine, Adacel, conferred similar protection against B. bronchiseptica challenge. These data indicate that in