candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients a prospective study候选基因关联研究antipsychotic-induced运动障碍长期精神病患者的前瞻性研究.pdfVIP

Candidate Gene-Based Association Study of Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients: A Prospective Study 1 2 3 3 4,5 P. Roberto Bakker *, Egbert Bakker , Najaf Amin , Cornelia M. van Duijn , Jim van Os , Peter N. van Harten1,4 1 Psychiatric Centre GGZ Centraal, Amersfoort, The Netherlands, 2 Center for Human and Clinical Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands, 3 Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, 4 Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands, 5 Department of Psychosis Studies, Institute of Psychiatry, King’s Health Partners, King’s College London, London, United Kingdom Abstract Objective: Four types of antipsychotic-induced movement disorders: tardive dyskinesia (TD), parkinsonism, akathisia and tardive dystonia, subtypes of TD (orofacial and limb truncal dyskinesia), subtypes of parkinsonism (rest tremor, rigidity, and bradykinesia), as well as a principal-factor of the movement disorders and their subtypes, were examined for association with variation in 10 candidate genes (PPP1R1B, BDNF, DRD3, DRD2, HTR2A, HTR2C, COMT, MnSOD, CYP1A2, and RGS2). Methods: Naturalistic study of 168 white long-stay patients with chronic mental illness requiring long-term antipsychotic treatment, examined by the same rater at least two times over a 4-year period, with a mean follow-up time of 1.1 years, with validated scales for TD, parkinsonism, akathisia, and tardive dystonia. The authors genotyped 31 SNPs, associated with movement disorders or schizophren