candidate human genetic polymorphisms and severe malaria in a tanzanian population候选人人类遗传多态性和严重疟疾在坦桑尼亚人口.pdfVIP

Candidate Human Genetic Polymorphisms and Severe Malaria in a Tanzanian Population 1,2. 2,3. 1,2 1 1 Alphaxard Manjurano , Taane G. Clark , Behzad Nadjm , George Mtove , Hannah Wangai , 3 4 2 1 5 Nuno Sepulveda , Susana G. Campino , Caroline Maxwell , Raimos Olomi , Kirk R. Rockett , 5 2 1,2 1,2 Anna Jeffreys , MalariaGen Consortium, Eleanor M. Riley , Hugh Reyburn , Christopher Drakeley * 1Joint Malaria Programme, Kilimanjaro Christian Medical Centre, Moshi, Tanzania, 2 Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, 3 Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom, 4 Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom, 5 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom Abstract Human genetic background strongly influences susceptibility to malaria infection and progression to severe disease and death. Classical genetic studies identified haemoglobinopathies and erythrocyte-associated polymorphisms, as protective against severe disease. High throughput genotyping by mass spectrometry allows multiple single nucleotide polymorphisms (SNPs) to be examined simultaneously. We compared the prevalence of 65 human SNP’s, pre