both functional ltβ receptor and tnf receptor 2 are required for the development of experimental cerebral malaria功能性ltβ受体和肿瘤坏死因子受体2所需实验脑型疟疾的发展.pdfVIP

Both Functional LTb Receptor and TNF Receptor 2 Are Required for the Development of Experimental Cerebral Malaria ´ 1. 2. 1 1 Dieudonnee Togbe , Paulo Loureiro de Sousa , Mathilde Fauconnier , Victorine Boissay , Lizette 3 4 4 5 6 2 Fick , Stefanie Scheu , Klaus Pfeffer , Robert Menard , Georges E. Grau , Bich-Thuy Doan , Jean Claude 2 6,8 6 6 6 1 Beloeil , Laurent Renia , Anna M. Hansen , Helen J. Ball , Nicholas H. Hunt , Bernhard Ryffel *, Valerie F. J. Quesniaux1* ´ ´ 1 University of Orleans and CNRS, Molecular Immunology and Embryology UMR6218, Orleans, France, 2 CNRS CBM (Centre de Biophysique Moleculaire), Orleans, France, 3 Institute of Infectious Disease and Molecular Medicine, Cape Town, South Africa, 4 University of Duesseldorf, Duesseldorf, Germany, 5 Pasteur Institute Paris, Paris, ´ France, 6 The University of Sydney, Department of Pathology, Camperdown, Australia, 7 Institut Cochin, Universite Paris Descartes, CNRS (UMR 8104), Paris, France, 8 Inserm, U567, Paris, France Abstract Background: TNF-related lymphotoxin a (LTa) is essential for the development of Plasmodium berghei ANKA (PbA)-induced experimental cerebral malaria (ECM). The pathway involved has been attributed to TNFR2. He