bayesian linkage analysis of categorical traits for arbitrary pedigree designs贝叶斯分类性状的连锁分析任意血统的设计.pdfVIP

Bayesian Linkage Analysis of Categorical Traits for Arbitrary Pedigree Designs 1 2 2 3 4 Abra Brisbin *, Myrna M. Weissman , Abby J. Fyer , Steven P. Hamilton , James A. Knowles , Carlos D. Bustamante1,5, Jason G. Mezey1,6 1 Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America, 2 Department of Psychiatry, College of Physicians and Surgeons, Columbia University and New York State Psychiatric Institute, New York, New York, United States of America, 3 Department of Psychiatry and Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America, 4 Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, 5 Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America, 6 Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America Abstract Background: Pedigree studies of complex heritable diseases often feature nominal or ordinal phenotypic measurements and missing genetic marker or phenotype data. Methodology: We have developed a Bayesian method for Linkage analysis of Ordinal and Categorical traits (LOCate) that can analyze complex genealogical structure for family groups and incorporate missing data. LOCate uses a Gibbs sampling approach to assess linkage, incorporating a simulated tempering algorithm for fast mixing. While our treatment is Bayesian, we develop a LOD (log of odds) score estimator for assessing linkage from Gibbs sampling that is highly accurate for simulated data. LOCate is applicable to linkage analysis for ordinal or nomina