bayesian latent class models in malaria diagnosis贝叶斯潜伏在疟疾诊断类模型.pdfVIP

Bayesian Latent Class Models in Malaria Diagnosis 1 2 ´ 2 ´ ´ 3 4 Luzia Gonc¸alves *, Ana Subtil , M. Rosario de Oliveira , Virgılio do Rosario , Pei-Wen Lee , Men-Fang Shaio5 ´ ´ ´ 1 CEAUL and Unidade de Saude Publica Internacional e Bioestatıstica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal, 2 CEMAT ´ ´ ´ ´ and Departamento de Matematica, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Lisboa, Portugal, 3 CMDT/LA and Unidade de Parasitologia Medica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal, 4 Institute of Biomedical Nutrition, HungKuang University, Taichung, Taiwan, 5 Department of Tropical Medicine, National Yang-Ming University, Taipei, Taiwan Abstract Aims: The main focus of this study is to illustrate the importance of the statistical analysis in the evaluation of the accuracy ˜ ´ of malaria diagnostic tests, without admitting a reference test, exploring a dataset (n ~3317) collected in Sao Tome and ´ Prıncipe. Methods: Bayesian Latent Class Models (without and with constraints) are used to estimate the malaria infection prevalence, together with sensitiviti