cell-type independent myc target genes reveal a primordial signature involved in biomass accumulation程控独立myc目标基因揭示原始签名参与生物量积累.pdfVIP

Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation 1 1 2 3 4 4 Hongkai Ji *, George Wu , Xiangcan Zhan , Alexandra Nolan , Cheryl Koh , Angelo De Marzo , Hoang 3 3 3 5 5 6 Mai Doan , Jinshui Fan , Christopher Cheadle , Mohammad Fallahi , John L. Cleveland , Chi V. Dang *, Karen I. Zeller3* 1 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, 2 Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine and Hugo W. Moser Research Institute at the Kennedy Krieger Institute, Baltimore, Maryland, United States of America, 3 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 4 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 5 Department of Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America, 6 Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America Abstract The functions of key oncogenic transcription factors independent of context have not been fully delineated despite our richer understanding of the genetic alterations in human cancers. The MYC oncogene, which produces the Myc transcription factor, is frequently altered in human cancer and is a major regulatory hub for many cancers. In this regard, we sought to unravel the primordial signature of Myc function by using hig