changes in the brain microstructure of children with primary monosymptomatic nocturnal enuresis a diffusion tensor imaging study大脑的变化组织的主单症状的患儿夜遗尿扩散张量成像研究.pdfVIP

Changes in the Brain Microstructure of Children with Primary Monosymptomatic Nocturnal Enuresis: A Diffusion Tensor Imaging Study 1. 2. 2 1 1 1 1 1 Du Lei , Jun Ma , Xiaoming Shen , Xiaoxia Du *, Guohua Shen , Wei Liu , Xu Yan , Gengying Li * 1 Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai, China, 2 Department of Developmental and Behavioral Pediatrics of Shanghai Children’s Medical Center, XinHua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Children’s Environmental Health, Shanghai, China Abstract Background: Primary monosymptomatic nocturnal enuresis (PMNE) is a common disorder in school-aged children. Previous studies have suggested that a developmental delay might play a role in the pathology of children with PMNE. However, microstructural abnormalities in the brains of these children have not been thoroughly investigated. Methodology/Principal Findings: In this work, we evaluated structural changes in the brains of children with PMNE using diffusion tensor imaging (DTI). Two groups consisting of 26 children with PMNE and 26 healthy controls were scanned using magnetic resonance DTI. The diffusion parameters of fractional anisotropy (FA) and mean diffusivity (MD) were subjected to whole-brain, voxel-wise group comparisons using statistical parametric mapping (SPM). When compared to healthy subjects, children with PMNE showed both a decrease in FA and an increase in MD in the thalamus. MD also increased in the frontal lobe, the anterior cingulate cortex and the insula; these areas are all involved in controlling micturition. The significa