canine genomics and genetics running with the pack狗的基因组学和遗传学与包运行.pdfVIP

Review Canine Genomics and Genetics: Running with the Pack Heidi G. Parker, Elaine A. Ostrander* ABSTRACT likelihood predictions to be 27 morgans in genetic distance [8]. Estimates based on flow sorting of chromosomes suggest a he domestication of the dog from its wolf ancestors is physical size of 2.8 gigabases [9,10]. Predictions based on perhaps the most complex genetic experiment in sequence analysis of euchromatic sequence suggest a size of Thistory, and certainly the most extensive. Beginning 2.3–2.4 gigabases [1,11]. Integrated linkage, radiation hybrid with the wolf, man has created dog breeds that are hunters or (RH), and cytogenetic maps of the dog genome confirmed herders, big or small, lean or squat, and independent or loyal. these general conclusions [12–15]. Most breeds were established in the 1800s by dog fanciers, Most recently a comparative RH map of the dog genome using a small number of founders that featured traits of containing 10,000 canine gene sequences has proven particular interest. Popular sire effects, population invaluable for identifying small rearrangements within the bottlenecks, and strict breeding programs designed to expand canine genome (http://www-recomgen.univ-rennes1.fr/doggy. populations with desirable traits led to the development of html) [16], as well as assisting in the ordering of contigs for the what are now closed breeding populations, with limited draft assembly [1]. The gene sequences used in construction of phenotypic and genetic heterogeneity, but which are ideal for the 10,000-gene RH map were derived from a 1.5