both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the epic-norfolk prospective population studyparaoxonase-1基因型和活动不预测未来冠状动脉疾病的风险;.pdfVIP

Both Paraoxonase-1 Genotype and Activity Do Not Predict the Risk of Future Coronary Artery Disease; the EPIC-Norfolk Prospective Population Study 1 1 1 6 6 Rakesh S. Birjmohun *, Menno Vergeer , Erik S. G. Stroes , Manjinder S. Sandhu , Sally L. Ricketts , 2 4 5 1 6 Michael W. Tanck , Nicholas J. Wareham , J. Wouter Jukema , John J. P. Kastelein , Kay-Tee Khaw , S. Matthijs Boekholdt3 1 Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands, 2 Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands, 3 Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands, 4 Medical Research Council Epidemiology Unit, Cambridge, United Kingdom, 5 Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, 6 Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom Abstract Background: Paraoxonase-1 (PON1) is an antioxidant enzyme, that resides on high-density lipoprotein (HDL). PON1-activity, is heavily influenced by the PON1-Q192R polymorphism. PON1 is considered to protect against atherosclerosis, but it is unclear whether this relation is independent of its carrier, HDL. In order to evaluate the atheroprotective potential of PON1, we assessed the relationships among PON1-genotype, PON1-activity and risk of future coronary artery disease (CAD), in a large prospective case-control study. Methodology/Principal Findings: Cases (n = 1138) were apparently healthy men and women aged 45–79 years who devel