characterization of a new camp factor carried by an integrative and conjugative element in streptococcus agalactiae and spreading in streptococci描述一个新的营地因素由一个综合和共轭元素链球菌agalactiae链球菌和传播.pdfVIP

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characterization of a new camp factor carried by an integrative and conjugative element in streptococcus agalactiae and spreading in streptococci描述一个新的营地因素由一个综合和共轭元素链球菌agalactiae链球菌和传播.pdf

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characterization of a new camp factor carried by an integrative and conjugative element in streptococcus agalactiae and spreading in streptococci描述一个新的营地因素由一个综合和共轭元素链球菌agalactiae链球菌和传播

Characterization of a New CAMP Factor Carried by an Integrative and Conjugative Element in Streptococcus agalactiae and Spreading in Streptococci 1,2,3 ` 2,3 1 1 2,3 Sarah Chuzeville , Aurore Puymege , Jean-Yves Madec , Marisa Haenni , Sophie Payot * ´ ´ ´ ´ ´ ´ 1 Unite Antibioresistance et Virulence Bacteriennes, Anses Lyon, Lyon, France, 2 INRA, UMR1128 Genetique et Microbiologie, Faculte des Sciences et Technologies, Bd des ` ´ ´ ´ ´ Aiguillettes BP70239, Vandœuvre-les-Nancy, France, 3 Universite de Lorraine, UMR1128 Genetique et Microbiologie, Faculte des Sciences et Technologies, Bd des ` Aiguillettes BP70239, Vandœuvre-les-Nancy, France Abstract Genetic exchanges between Streptococci occur frequently and contribute to their genome diversification. Most of sequenced streptococcal genomes carry multiple mobile genetic elements including Integrative and Conjugative Elements (ICEs) that play a major role in these horizontal gene transfers. In addition to genes involved in their mobility and regulation, ICEs also carry genes that can confer selective advantages to bacteria. Numerous elements have been described in S. agalactiae especially those integrated at the 39 end of a tRNALys encoding gene. In strain 515 of S. agalactiae, an invasive neonate human pathogen, the ICE (called 515_tRNALys) is functional and carries different putative virule