原创力文档chromosomal and plasmid-encoded factors of shigella flexneri induce secretogenic activity ex vivo弗氏志贺菌的染色体和plasmid-encoded因素诱发体外secretogenic活动.pdfVIP
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chromosomal and plasmid-encoded factors of shigella flexneri induce secretogenic activity ex vivo弗氏志贺菌的染色体和plasmid-encoded因素诱发体外secretogenic活动
Chromosomal and Plasmid-Encoded Factors of Shigella
flexneri Induce Secretogenic Activity Ex Vivo
1. 2. 2 1 3
Christina Faherty , Jill M. Harper , Terez Shea-Donohue , Eileen M. Barry , James B. Kaper ,
Alessio Fasano2*, James P. Nataro1¤
1 Department of Medicine, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, 2 Mucosal Biology
Research Center, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, 3 Department of Microbiology and Immunology, University of
Maryland School of Medicine, Baltimore, Maryland, United States of America
Abstract
Shigella flexneri is a Gram-negative, facultative intracellular pathogen that causes millions of cases of watery or bloody
diarrhea annually, resulting in significant global mortality. Watery diarrhea is thought to arise in the jejunum, and
subsequent bloody diarrhea occurs as a result of invasion of the colonic epithelium. Previous literature has demonstrated
that Shigella encodes enterotoxins, both chromosomally and on the 220 kilobase virulence plasmid. The Shigella
Enterotoxins 1 and 2 (ShET1 and ShET2) have been shown to increase water accumulation in the rabbit ileal loop model. In
addition, these toxins increase the short circuit current in rabbit tissue mounted in Ussing chambers, which is a model for
the ion exchange that occurs during watery diarrhea. In this study, we sought to validate the use of mouse jejunum in
Ussing chamber as an alternative, more versatile model to study bacterial pathogenesis. In the process, we also identified
enterotoxins in addition to ShET1 and ShET2 encoded b
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