chromosome 2p14 is linked to susceptibility to leprosy染色体2好对麻风病的易感性有关.pdfVIP

Chromosome 2p14 Is Linked to Susceptibility to Leprosy 1,2,3,4. 1,2,3,4. 5 6 1,2,3,4 1,2,3,4 Qing Yang , Hong Liu , Hui-Qi Low , Haifeng Wang , Yongxiang Yu , Xi’an Fu , 1,2,3,4 1,2,3,4 1,2,3,4 1,2,3,4 6 5 Gongqi Yu , Mingfei Chen , Xiaoxiao Yan , Shumin Chen , Wei Huang , Jianjun Liu , Furen Zhang1,2,3,4* 1 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Science, Jinan, Shandong, China, 2 Shandong Provincial Hospital for Skin Diseases, Jinan, Shandong, China, 3 Shandong Provincial key lab of Dermato-venereology, Jinan, Shandong, China, 4 Shandong Provincial Medical Center for Dermatovenereology, Jinan, Shandong, China, 5 Department of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, 6 Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China Abstract Background: A genetic component to the etiology of leprosy is well recognized but the mechanism of inheritance and the genes involved are yet to be fully established. Methodology: A genome-wide single nucleotide polymorphism (SNP) based linkage analysis was carried out using 23 pedigrees, each with 3 to 7 family members affected by leprosy. Multipoint parametric and non-parametric linkage analyses were performed using MERLIN 1.1.1. Principal Findings: Genome-wide significant evidence for linkage was identified on chromosome 2p14 with a heterogeneity logarithm