chronic obstructive pulmonary disease is associated with low levels of vitamin d慢性阻塞性肺疾病与低水平的维生素d.pdfVIP

Chronic Obstructive Pulmonary Disease Is Associated with Low Levels of Vitamin D 1 1 3 1,2 Louise Jeanette Pauline Persson *, Marianne Aanerud , Pieter Sicco Hiemstra , Jon Andrew Hardie , Per Sigvald Bakke2, Tomas Mikal Lind Eagan1,2 1 Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway, 2 Institute of Medicine, University of Bergen, Bergen, Norway, 3 Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands Abstract Introduction: COPD patients may be at increased risk for vitamin D (25(OH)D) deficiency, but risk factors for deficiency among COPD patients have not been extensively reported. Methods: Serum 25(OH)D levels were measured by liquid chromatography double mass spectrometry in subjects aged 40– 76 years from Western Norway, including 433 COPD patients (GOLD stage II-IV) and 325 controls. Levels ,20 ng/mL defined deficiency. Season, sex, age, body mass index (BMI), smoking, GOLD stage, exacerbation frequency, arterial oxygen tension (PaO2), respiratory symptoms, depression (CES-D score$16), comorbidities (Charlson score), treatment for osteoporosis, use of inhaled steroids, and total white blood count were examined for associations with 25(OH)D in both linear and logistic regression models. Results: COPD patients had an increased risk for vitamin D deficiency compared to controls after adjustment for seasonality, age, smoking and BMI. Variables associated with lower 25(OH)D levels in COPD patients were obesity ( = 26.63), current smoking ( = 24.02), GOLD stage III- IV ( = 24.71, = 25.64), and depression ( = 23.29). Summertime decreased the risk of vitamin D