chronic temporal lobe epilepsy is associated with enhanced alzheimer-like neuropathology in 3×tg-ad mice慢性颞叶癫痫与增强的类似于神经病理学在3×tg-ad老鼠.pdfVIP

Chronic Temporal Lobe Epilepsy Is Associated with Enhanced Alzheimer-Like Neuropathology in 3 6Tg-AD Mice 1 1,2,3 3 1 1 4 Xiao-Xin Yan *, Yan Cai , Jarod Shelton , Si-Hao Deng , Xue-Gang Luo , Salvatore Oddo , 5 6 2,3 2,3 Frank M. LaFerla , Huaibin Cai , Gregory M. Rose *, Peter R. Patrylo * 1 Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan, China, 2 Center for Integrated Research in Cognitive and Neural Sciences, Southern Illinois University Carbondale, Illinois, United States of America, 3 Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois, United States of America, 4 Department of Physiology and The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, 5 Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, United States of America, 6 Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America Abstract The comorbidity between epilepsy and Alzheimer’s disease (AD) is a topic of growing interest. Senile plaques and tauopathy are found in epileptic human temporal lobe structures, and individuals with AD have an increased incidence of spontaneous seizures. However, why and how epilepsy is associated with enhanced AD-like pathology remains unknown. We have recently shown b-secretase-1 (BACE1) elevation associated with aberrant limbic axonal sprouting in epileptic CD1 mice. Here we sought to explore whether BACE1 u