changes in antibody seroprevalence of seven high-risk hpv types between nationwide surveillance studies from 1995–96 and 2006–07 in the netherlands抗体的变化之间的七种高危人乳头状瘤病毒类型seroprevalence全国监测研究从1995 - 96和2006 - 07年在荷兰.pdfVIP

Changes in Antibody Seroprevalence of Seven High-Risk HPV Types between Nationwide Surveillance Studies from 1995–96 and 2006–07 in The Netherlands 1,3 2,3 1 1 3 Mirte Scherpenisse *, Madelief Mollers , Rutger M. Schepp , Hein J. Boot , Chris J. L. M. Meijer , 1 1 2 Guy A. M. Berbers , Fiona R. M. van der Klis , Hester E. de Melker 1 Laboratory for Infectious Diseases and Screening, National Institute of Public Health and the Environment, Bilthoven, The Netherlands, 2 Department of Epidemiology and Surveillance, National Institute of Public Health and the Environment, Bilthoven, The Netherlands, 3 Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands Abstract Objective: This study evaluates trends in antibody seroprevalences of seven high-risk human papillomavirus (hr-HPV) serotypes (HPV16, 18, 31, 33, 45, 52, and 58) between the 1995–96 and 2006–07 sero-surveys among the Dutch general population in the pre-vaccination era. Methods: Serum samples of men and women (0–79 years of age) from two cross-sectional population-based serosurveillance studies performed in 1995–96 (n = 3303) and 2006–07 (n = 6384) were tested for HPV-specific antibodies in a VLP-based multiplex immunoassay. Results: HPV16-specific antibody seroprevalence increased during adolescence and shifted to younger ages in the 2006–07 survey compared to the 1995–96 survey. This step-up in HPV16 seroprevalence was most pronounced in women, while a more gradual increase was observed in men. Also in cohorts older than 49 years, HPV16 seroprevalence was higher in 2006– 07 as