cancer-drug associations a complex system抗癌药物协会一个复杂的系统.pdfVIP

Cancer-Drug Associations: A Complex System Ertugrul Dalkic1,2,3, Xuewei Wang1,4, Neil Wright1,5, Christina Chan1,2,3,4,6,7* 1 Center for Systems Biology, Michigan State University, East Lansing, Michigan, United States of America, 2 Cellular and Molecular Biology Lab, Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan, United States of America, 3 Cell and Molecular Biology Program, Michigan State University, East Lansing, Michigan, United States of America, 4 Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan, United States of America, 5 Department of Mechanical Engineering, Michigan State University, East Lansing, Michigan, United States of America, 6 Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, United States of America, 7 Department of Computer Science and Engineering, Michigan State University, East Lansing, Michigan, United States of America Abstract Background: Network analysis has been performed on large-scale medical data, capturing the global topology of drugs, targets, and disease relationships. A smaller-scale network is amenable to a more detailed and focused analysis of the individual members and their interactions in a network, which can complement the global topological descriptions of a network system. Analysis of these smaller networks can help address questions, i.e., what governs the pairing of the different cancers and drugs, is it driven by molecular findings or other factors, such as death statistics. Methodology/Principal Findings: We defined global and local lethality values representing death rates relative to other cancers vs. within a cancer. We generated two cancer networks, one of cancer types that share Food and